BDBM535737 6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy-1-(1-methyl-1H-pyrazol- 4-yl)prop-2-en-1-yl]-3-oxo-1-[cis-3- hydroxycyclobutoxy]-2,3-dihydro-1H- isoindol-2-yl]methyl}pyridine-3- carbonitrile Ex. 361 is the slower eluting isomer::US11236047, Example 361::US20230338337, Compound 361

SMILES C=CC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ccc(C#N)cn1)[C@@]2(O[C@H]1C[C@@H](O)C1)c1ccc(Cl)cc1)c1cnn(C)c1

InChI Key InChIKey=CBSMDIHLXRBTIK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535737   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535737BDBM535737(6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy...)
Affinity DataIC50: 3.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535737BDBM535737(6-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy...)
Affinity DataIC50: 3.90nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent