BDBM535751 2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy-1-(1-methyl-1H- imidazol-4-yl)propyl]-3-oxo-1-[(3S)- oxolan-3-yloxy]-2,3-dihydro-1H- isoindol-2-yl]methyl}pyrimidine-5- carbonitrile Ex. 369 is the slower eluting isomer::US11236047, Example 369

SMILES CCC(O)(c1cn(C)cn1)c1cc2C(=O)N(Cc3ncc(cn3)C#N)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=XUQLKCXDANADHI-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535751   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandPNGBDBM535751(2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy...)
Affinity DataIC50: 0.610nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
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Date in BDB:
6/6/2022
Entry Details
US Patent