BDBM535760 US11236047, Example 441::US11236047, Example 442

SMILES Cn1cc(cn1)C(O)(CF)c1ccc2c(c1)C(=O)N(Cc1ccc(cn1)C#N)[C@@]2(O[C@H]1CCOC1)c1ccc(Cl)cc1

InChI Key InChIKey=YVIAFQAKHVRQOG-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535760   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535760BDBM535760(US11236047, Example 442 | US11236047, Example 441)
Affinity DataIC50: 3.40nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535760BDBM535760(US11236047, Example 442 | US11236047, Example 441)
Affinity DataIC50: 12nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent