BDBM535768 2-(4-{1-[(1R)-1-(4-chlorophenyl)-2-[(5- chloropyridin-2-yl)methyl]-7-fluoro-1- methoxy-3-oxo-2,3-dihydro-1H- isoindol-5-yl]-1- hydroxyethyl}piperidin-1-yl)acetic acid Ex. 459 is the slower eluting isomer::US11236047, Example 459::US20230338337, Compound 459

SMILES CO[C@]1(N(Cc2ccc(Cl)cn2)C(=O)c2cc(cc(F)c12)C(C)(O)C1CCN(CC(O)=O)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=LEBZOJICUSODDT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535768   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535768BDBM535768(2-(4-{1-[(1R)-1-(4-chlorophenyl)-2-[(5- chloropyri...)
Affinity DataIC50: 2nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535768BDBM535768(2-(4-{1-[(1R)-1-(4-chlorophenyl)-2-[(5- chloropyri...)
Affinity DataIC50: 2nMAssay Description:Each assay was performed in a final volume of 20 μL in assay buffer containing 20 mM Tris-HCl (pH 8.0, (1M Tris-HCl, pH 8.0 solution; Corning 46...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2023
Entry Details
US Patent