BDBM535776 2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy-1-(1-methyl-1H- imidazol-4-yl)propyl]-3-oxo-1-[trans-3- (hydroxymethyl)cyclobutoxy]-2,3- dihydro-1H-isoindol-2- yl]methyl}pyrimidine-5-carbonitrile::US11236047, Example 481

SMILES CCC(O)(c1cc(F)c2c(c1)C(=O)N(Cc1ncc(C#N)cn1)[C@@]2(O[C@H]1C[C@H](CO)C1)c1ccc(Cl)cc1)c1cn(C)cn1

InChI Key InChIKey=LWGPMDOLLXQRCR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 535776   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535776BDBM535776(2-{[(1R)-1-(4-chlorophenyl)-7-fluoro- 5-[1-hydroxy...)
Affinity DataIC50: 1.40nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent