BDBM535788 (3R)-3-(4-chlorophenyl)-2-[(5- chloropyrimidin-2-yl)methyl]-6-[1- (dimethylamino)-2-hydroxybutan-2- yl]-4-fluoro-3-[(3S)-oxolan-3-yloxy]- 2,3-dihydro-1H-isoindol-1-one::US11236047, Example 528::US11236047, Example 529

SMILES CCC(O)(CN(C)C)c1cc2C(=O)N(Cc3ncc(Cl)cn3)[C@](O[C@H]3CCOC3)(c2c(F)c1)c1ccc(Cl)cc1

InChI Key InChIKey=IMWIKKNQOUEPQC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 535788   

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535788BDBM535788(US11236047, Example 529 | (3R)-3-(4-chlorophenyl)-...)
Affinity DataIC50: 2.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2(Human)
Astex Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 535788BDBM535788(US11236047, Example 529 | (3R)-3-(4-chlorophenyl)-...)
Affinity DataIC50: 28nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 ul per well of 1 μg ml−1 biotinylated IP3 pep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/6/2022
Entry Details
US Patent