BDBM5359 5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine::ACS Chemical Biology 3180 Compound 60::aminothiazole 19

SMILES Brc1cnc(Nc2ccccn2)s1

InChI Key InChIKey=WZNOXZQMWMMJMJ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5359   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5359(5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine | ACS...)
Affinity DataIC50: 71nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2005
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Novartis

LigandPNGBDBM5359(5-bromo-N-(pyridin-2-yl)-1,3-thiazol-2-amine | ACS...)
Affinity DataIC50: 2.00E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed