BDBM5362 2-(pyridin-2-ylamino)-1,3-thiazole-5-carbonitrile::ACS Chemical Biology 3180 Compound 63::aminothiazole 22

SMILES N#Cc1cnc(Nc2ccccn2)s1

InChI Key InChIKey=DJUPCZRMXNBXKZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5362   

TargetVascular endothelial growth factor receptor 2(Human)
Merck Research Laboratories

LigandPNGBDBM5362(ACS Chemical Biology 3180 Compound 63 | 2-(pyridin...)
Affinity DataIC50: 36nMpH: 7.4 T: 2°CAssay Description:Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2005
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Novartis

LigandPNGBDBM5362(ACS Chemical Biology 3180 Compound 63 | 2-(pyridin...)
Affinity DataIC50: 2.50E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with Aurora A and substrates in the presence ATP/[gamma-33P] ATP. After incubatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/24/2008
Entry Details Article
PubMed