BDBM536208 2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methylisoxazol-5-yl)butanoyl)pyrrolidin-2-yl)-5-methyl-5-(4-(2-methylpyridin-3-yl)phenyl)-1,5-dihydro-4H-imidazol-4-one::US11242344, Example 106.1

SMILES Cc1cc(C(C(=O)N2C[C@H](O)C[C@H]2C2=NC(=O)[C@](C)(c3ccc(-c4cccnc4C)cc3)N2)C(C)C)on1

InChI Key InChIKey=WPZOEZCNSSMQBG-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 536208   

LigandChemical structure of BindingDB Monomer ID 536208BDBM536208(2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methylisoxazol-...)
Affinity DataKd: >1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536208BDBM536208(2-((4R)-4-Hydroxy-1-(3-methyl-2-(3-methylisoxazol-...)
Affinity DataIC50: 4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent