BDBM536227 (2S)-1-((2S,4R)-2-(2,3-dihydro-4'H-spiro[indene-1,5'-[1,2,4]oxadiazol]-3'-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 130.1::US11242344, Example 130.2

SMILES Cc1cc([C@@H](C(=O)N2C[C@H](O)C[C@H]2C2=NOC3(CCc4ccccc43)N2)C(C)C)on1

InChI Key InChIKey=JNTHBMXTLMHJGI-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536227   

LigandChemical structure of BindingDB Monomer ID 536227BDBM536227(US11242344, Example 130.2 | (2S)-1-((2S,4R)-2-(2,3...)
Affinity DataKd:  8.30E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536227BDBM536227(US11242344, Example 130.2 | (2S)-1-((2S,4R)-2-(2,3...)
Affinity DataIC50: 9.61E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536227BDBM536227(US11242344, Example 130.2 | (2S)-1-((2S,4R)-2-(2,3...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536227BDBM536227(US11242344, Example 130.2 | (2S)-1-((2S,4R)-2-(2,3...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536227BDBM536227(US11242344, Example 130.2 | (2S)-1-((2S,4R)-2-(2,3...)
Affinity DataKd:  1.21E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536227BDBM536227(US11242344, Example 130.2 | (2S)-1-((2S,4R)-2-(2,3...)
Affinity DataIC50: 3.62E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent