BDBM536236 US11242344, Example 110.3

SMILES Cc1ncsc1-c1ccc([C@]2(C)NC([C@@H]3C[C@@H](O)CN3C(=O)[C@H](c3cnn(C)c3)C(C)C)=NC2=O)cc1

InChI Key InChIKey=HAPGPSOTLKJYEI-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536236   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536236BDBM536236(US11242344, Example 110.3)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536236BDBM536236(US11242344, Example 110.3)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536236BDBM536236(US11242344, Example 110.3)
Affinity DataIC50: 4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent