BDBM536245 (R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-oxadiazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 132.2

SMILES Cc1cc([C@H](C(=O)N2C[C@H](O)C[C@H]2C2=NOC(c3ccccc3)(c3ccccc3)N2)C(C)C)on1

InChI Key InChIKey=QLVWODLSBTTWFS-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536245   

LigandChemical structure of BindingDB Monomer ID 536245BDBM536245((R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-o...)
Affinity DataKd:  1.26E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536245BDBM536245((R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-o...)
Affinity DataIC50: 3.94E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536245BDBM536245((R)-1-((2S,4R)-2-(5,5-diphenyl-4,5-dihydro-1,2,4-o...)
Affinity DataIC50: 4.57E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent