BDBM536259 1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4-hydroxypyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl)butan-1-one::US11242344, Example 135.1::US11242344, Example 135.2

SMILES CC(C)C(C(=O)N1C[C@H](O)C[C@H]1C1=NN(c2ccccc2)C(C)(C)N1)c1cc(C)no1

InChI Key InChIKey=YYPSIGSWLYJIDY-UHFFFAOYSA-N

Data  4 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 536259   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataIC50: 5.67E+3nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataKd:  6.55E+3nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataIC50: 9.32E+3nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandPNGBDBM536259(1-((2S,4R)-2-(5,5-dimethyl-1-phenyl-4,5-dihydro-1H...)
Affinity DataIC50: 4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent