BDBM536263 1-((4R)-4-Hydroxy-2-(4,4,5,5-tetramethyl-4,5-dihydro-1H-imidazol-2-yl) pyrrolidin-1-yl)-3-methyl-2-(3-methylisoxazol-5-yl) butan-1-one (Mixture of 4 Stereoisomers)::US11242344, Example 136.1

SMILES Cc1cc(C(C(=O)N2C[C@H](O)CC2C2=NC(C)(C)C(C)(C)N2)C(C)C)on1

InChI Key InChIKey=RMPVDBRTXPUCMQ-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536263   

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536263BDBM536263(1-((4R)-4-Hydroxy-2-(4,4,5,5-tetramethyl-4,5-dihyd...)
Affinity DataIC50: 7.71E+4nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536263BDBM536263(1-((4R)-4-Hydroxy-2-(4,4,5,5-tetramethyl-4,5-dihyd...)
Affinity DataIC50: 9.36E+4nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536263BDBM536263(1-((4R)-4-Hydroxy-2-(4,4,5,5-tetramethyl-4,5-dihyd...)
Affinity DataKd:  1.50E+5nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent