BDBM536283 4-(2-((5-(1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(4-methylthiazol-5-yl)phenyl)-4-oxo-4,5-dihydro-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)isoxazol-3-yl)oxy)ethoxy)-N-(2-(4-((Z)-1-(4-hydroxyphenyl)-2-phenylbut-1-en-1-yl)phenoxy)ethyl)-N-methylbutanamide::US11242344, Example 1003.1

SMILES CC/C(=C(\c1ccc(O)cc1)c1ccc(OCCN(C)C(=O)CCCOCCOc2cc([C@H](C(=O)N3C[C@H](O)C[C@H]3C3=NC(=O)[C@](C)(c4ccc(-c5scnc5C)cc4)N3)C(C)C)on2)cc1)c1ccccc1

InChI Key InChIKey=YNNSZAHUAIODTC-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 536283   

LigandChemical structure of BindingDB Monomer ID 536283BDBM536283(4-(2-((5-(1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(...)
Affinity DataKd:  6.71E+4nMAssay Description:Using a Biacore T200, Avidin tagged VHL co-expressed with Elongins B and C were immobilized to a Biacore SA chip in running buffer without DMSO. Comp...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

Targetvon Hippel-Lindau disease tumor suppressor(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536283BDBM536283(4-(2-((5-(1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(...)
Affinity DataIC50: 1.00E+5nMAssay Description:The VHL NanoBRET Target Engagement Assay analyzes the apparent affinity of test compounds for VHL in cells by competitive displacement of a VHL NanoB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent

LigandChemical structure of BindingDB Monomer ID 536283BDBM536283(4-(2-((5-(1-((4R)-4-hydroxy-2-((S)-5-methyl-5-(4-(...)
Affinity DataIC50: 4.00E+5nMAssay Description:The binding of test compounds to the VHL Elongin B/C complex was measured using a fluorescence polarization tracer competition assay. The VHL/Elongin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2022
Entry Details
US Patent