BDBM536868 1-(3-(6-(difluoromethyl)-2-methyl-5-(1-methyl-1H-pyrazol-4-yl)-1H-indol-1-yl)-1-(tetrahydro-2H-pyran-4-yl)-6,7-dihydro-1H-pyrazolo[4,3-c]pyridin-5(4H)-yl)ethanone::US11247989, Example 42

SMILES CC(=O)N1CCc2c(c(-n3c(C)cc4cc(-c5cnn(C)c5)c(C(F)F)cc43)nn2C2CCOCC2)C1

InChI Key InChIKey=UNSOLAMOWLJBFZ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 536868   

TargetCREB-binding protein(Human)
Genentech

US Patent
LigandChemical structure of BindingDB Monomer ID 536868BDBM536868(1-(3-(6-(difluoromethyl)-2-methyl-5-(1-methyl-1H-p...)
Affinity DataIC50: 10.4nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent