BDBM540288 US11261186, Example 215

SMILES C[C@@H]1Cc2ccnc(c2)-c2cnc3ccc(nn23)N2C[C@@H](F)C[C@@H]2c2cc(F)cnc2O1

InChI Key InChIKey=YLATTZPQJPGMOP-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540288   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540288BDBM540288((32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540288BDBM540288((32R,34S,6R,E)-34,45-difluoro-6-methyl-5-oxa-2(3,6...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent