BDBM540292 US11261186, Example 219

SMILES C[C@H]1Nc2ccc3ncc(n3n2)-c2cc(ccn2)N2CCC[C@@H](C2)Oc2ccc(F)cc21

InChI Key InChIKey=FQDRGMJEDSWXBT-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540292   

TargetHigh affinity nerve growth factor receptor(Human)
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540292BDBM540292((33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-i...)
Affinity DataIC50: 3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent

TargetHigh affinity nerve growth factor receptor NTRK1 [F589L](Homo sapiens (Human))
Suzhou Langrui Biopharmaceutical

US Patent
LigandChemical structure of BindingDB Monomer ID 540292BDBM540292((33S,6R,E)-54-fluoro-6-methyl-4-oxa-7-aza-1(3,6)-i...)
Affinity DataIC50: 5nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent