BDBM540563 US11261186, Example 499

SMILES COC1(COc2ccc(S(=O)(=O)NC(=O)c3ccc(N4CCN5CC6=C(c7ccc(Cl)cc7)CC(C)(C)C[C@H]6OCCCOC[C@@H]5C4)cc3N3CCCOc4nc5[nH]ccc5cc43)cc2[N+](=O)[O-])CCOCC1

InChI Key InChIKey=QEQJAXBIIAUTLE-UHFFFAOYSA-N

Data  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 540563   

TargetApoptosis regulator Bcl-2(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 540563BDBM540563(US20260028356, Example 51)
Affinity DataKi:  0.100nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent

TargetBcl-2-like protein 1(Human)
Abbvie

US Patent
LigandChemical structure of BindingDB Monomer ID 540563BDBM540563(US20260028356, Example 51)
Affinity DataKi:  18.9nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center Affiliation: UT Southwestern Assay Provider: David Mangelsdorf,...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/10/2026
Entry Details US Patent