BDBM542482 US11274095, Example 14-Enantiomer-1::US11274095, Example 14-Enantiomer-2

SMILES CSc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(Cl)c2OC(C)(Oc2c1C)C1CCN(CC(F)(F)F)CC1

InChI Key InChIKey=IJJMMMCKJPROJX-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 542482   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM542482(US11274095, Example 14-Enantiomer-2 | US11274095, ...)
Affinity DataIC50: 0.0370nMAssay Description:EZH2 biochemical assay (IC50): Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent

TargetHistone-lysine N-methyltransferase EZH2(Human)
Constellation Pharmaceuticals

US Patent
LigandPNGBDBM542482(US11274095, Example 14-Enantiomer-2 | US11274095, ...)
Affinity DataIC50: 7nMAssay Description:EZH2 biochemical assay (IC50): Compound potencies were assessed through incorporation of 3H-SAM into a biotinylated H3 peptide. Specifically, 30 pM P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2022
Entry Details
US Patent