BDBM543833 2-((6-((6-bromo-5-fluorobenzo[d]thiazol-2-yl)amino)spiro[3.3]heptan-2-yl)oxy)nicotinamide::US11299488, Example 1

SMILES NC(=O)c1cccnc1OC1CC2(CC(C2)Nc2nc3cc(F)c(Br)cc3s2)C1

InChI Key InChIKey=PNRCARHOBGABQS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 543833   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM543833(2-((6-((6-bromo-5-fluorobenzo[d]thiazol-2-yl)amino...)
Affinity DataIC50: 547nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2022
Entry Details
US Patent