BDBM544275 US11285140, Example 273

SMILES N#CCC1(n2ccc(-c3ncnc4[nH]ccc34)c2)CN(C2CCN(Cc3cc(C(F)(F)F)ccc3F)CC2)C1

InChI Key InChIKey=UYGUNLYBBUSGBS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 544275   

TargetTyrosine-protein kinase JAK1 [837-1142](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 544275BDBM544275(US11285140, Example 273)
Affinity DataIC50: 5nMAssay Description:Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent

TargetTyrosine-protein kinase JAK2 [828-1132](Human)
Incyte

US Patent
LigandChemical structure of BindingDB Monomer ID 544275BDBM544275(US11285140, Example 273)
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/16/2022
Entry Details
US Patent