BDBM5449 6-alkoxy-4-anilinoquinazoline 7a::N-{4-[(4-{[4-(benzyloxy)phenyl]amino}quinazolin-6-yl)oxy]butyl}-2,2,2-trifluoro-N-(2-methanesulfonylethyl)acetamide

SMILES CS(=O)(=O)CCN(CCCCOc1ccc2ncnc(Nc3ccc(OCc4ccccc4)cc3)c2c1)C(=O)C(F)(F)F

InChI Key InChIKey=XUAWYHMIPSETPV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 5449   

TargetEpidermal growth factor receptor(Human)
Glaxosmithkline

LigandPNGBDBM5449(N-{4-[(4-{[4-(benzyloxy)phenyl]amino}quinazolin-6-...)
Affinity DataIC50: 263nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Glaxosmithkline

LigandPNGBDBM5449(N-{4-[(4-{[4-(benzyloxy)phenyl]amino}quinazolin-6-...)
Affinity DataIC50: 977nMpH: 7.5 T: 2°CAssay Description:Enzymatic reactions were initiated by adding kinase to the reaction mixture containing ATP, [gamma-33P] ATP, peptide substrate and test inhibitor com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2005
Entry Details Article
PubMed