BDBM549053 2-(((2S,4s,6S)-6-((5-(3,4- difluorophenyl)-1,3,4- oxadiazol-2-yl) amino)spiro[3.3]heptan-2- yl)oxy)nicotinainide::US11299488, Example 18

SMILES NC(=O)c1cccnc1O[C@H]1C[C@@]2(C[C@@H](C2)Nc2nnc(o2)-c2ccc(F)c(F)c2)C1

InChI Key InChIKey=HUEFLIPLCNXFGR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549053   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549053(2-(((2S,4s,6S)-6-((5-(3,4- difluorophenyl)-1,3,4- ...)
Affinity DataIC50: 326nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
7/24/2022
Entry Details
US Patent