BDBM549082 2-(((2S,4s,6S)- 6-((6- fluoro- quinazolin- 4- yl)amino) spiro[3.3] heptan-2- yl)oxy) nicotinamide::US11299488, Example 26

SMILES NC(=O)c1cccnc1O[C@H]1C[C@@]2(C[C@@H](C2)Nc2ncnc3ccc(F)cc23)C1

InChI Key InChIKey=JLVSAEGUJAPXIE-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549082   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549082(2-(((2S,4s,6S)- 6-((6- fluoro- quinazolin- 4- yl)a...)
Affinity DataIC50: 128nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
7/24/2022
Entry Details
US Patent