BDBM549131 2-(((2S,4s, 6S)- 6-((6- methyl- isoquinolin- 1- yl)amino)spiro [3.3] heptan-2- yl)oxy) nicotinamide::US11299488, Example 31

SMILES Cc1ccc2c(N[C@H]3C[C@]4(C3)C[C@@H](C4)Oc3ncccc3C(N)=O)nccc2c1

InChI Key InChIKey=GDRUWRNBBXHMGR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549131   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549131(2-(((2S,4s, 6S)- 6-((6- methyl- isoquinolin- 1- yl...)
Affinity DataIC50: 47nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
7/24/2022
Entry Details
US Patent