BDBM549141 2-(((2S,4s, 6S)-6- ((3,6- dimethoxy- isoquinolin- 1-y])amino) spiro[3.3] heptan-2- yl)oxy) nicotinamide::US11299488, Example 32

SMILES COc1ccc2c(N[C@H]3C[C@]4(C3)C[C@@H](C4)Oc3ncccc3C(N)=O)nc(OC)cc2c1

InChI Key InChIKey=NDJRCCPSCSBCAT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 549141   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM549141(2-(((2S,4s, 6S)-6- ((3,6- dimethoxy- isoquinolin- ...)
Affinity DataIC50: 68nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
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Date in BDB:
7/24/2022
Entry Details
US Patent