BDBM550454 (2R)-2-((8R,9aS)-8-acetamido-1-oxo-5-phenethylhexahydro-1H-pyrrolo[1,2-a][1,4]diazepin-2(3H)-yl)-N-(3,4-dichlorobenzyl)-4-methylpentanamide HCl::US11306098, Example 20::US11583538, Example 127

SMILES CC(C)C[C@@H](N1CCC(CCc2ccccc2)N2C[C@@H](C[C@H]2C1=O)NC(C)=O)C(=O)NCc1ccc(Cl)c(Cl)c1

InChI Key InChIKey=QOHUQFUPFBJOSU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 550454   

TargetThree-prime repair exonuclease 1(Human)
Venenum Biodesign

US Patent
LigandPNGBDBM550454((2R)-2-((8R,9aS)-8-acetamido-1-oxo-5-phenethylhexa...)
Affinity DataIC50: 5.50E+3nMAssay Description:To evaluate the effect of compounds on TREX1 activity, test compounds were serially diluted (11-point, 3-fold) from 10 mM stock solutions and deliver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2022
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Human)
Venenum Biodesign

US Patent
LigandPNGBDBM550454((2R)-2-((8R,9aS)-8-acetamido-1-oxo-5-phenethylhexa...)
Affinity DataIC50: 5.50E+3nMAssay Description:For human TREX1, the nucleotide sequence of the gene construct was codon optimized for expression in the bacterial host. The sequence was incorporate...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/9/2023
Entry Details
US Patent

TargetThree-prime repair exonuclease 1(Mouse)
Venenum Biodesign

US Patent
LigandPNGBDBM550454((2R)-2-((8R,9aS)-8-acetamido-1-oxo-5-phenethylhexa...)
Affinity DataIC50: 5.50E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2022
Entry Details
US Patent