BDBM550569 6′-[(6-{[(3R)-3-(Dimethylamino)pyrrolidin-1-yl]carbonyl}thieno[2,3-d]pyrimidin-4-yl)amino]-8′-methyl-2′H-spiro[cyclopentane-1,3′-imidazo[1,5-a]pyridine]-1′,5′-dione::US11311520, Example 63

SMILES CN(C)[C@@H]1CCN(C1)C(=O)c1cc2c(Nc3cc(C)c4C(=O)NC5(CCCC5)n4c3=O)ncnc2s1

InChI Key InChIKey=CDCQKJQVYUUEDH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550569   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM550569(6′-[(6-{[(3R)-3-(Dimethylamino)pyrrolidin-1-...)
Affinity DataIC50: 3.80nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
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Date in BDB:
8/6/2022
Entry Details
US Patent