BDBM550702 8-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-2′,3′,5′,6′-tetrahydro-2H-spiro[imidazo[1,5-a]pyridine-3,4′-thiopyran]-1,5-dione::US11311520, Example 196

SMILES Cc1cc(Nc2ncnc3[nH]ccc23)c(=O)n2c1C(=O)NC21CCSCC1

InChI Key InChIKey=QYQZEPULBTZQQB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 550702   

TargetMAP kinase-interacting serine/threonine-protein kinase 1(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM550702(8-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-...)
Affinity DataIC50: 0.5nMAssay Description:MKNK1-inhibitory activity at high ATP of compounds of the present invention after their preincubation with MKNK1 was quantified employing the TR-FRET...More data for this Ligand-Target Pair
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Date in BDB:
8/6/2022
Entry Details
US Patent