BDBM550716 US11311527, Cpd ID I-6::US11376246, Cpd ID I-6::US11576906, Compound I-6

SMILES Cc1ccc(NCc2cc3cc(Cl)ccc3[nH]c2=O)c(=O)n1C

InChI Key InChIKey=HONGYFQTPGJGNF-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 550716   

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 550716BDBM550716(US11376246, Cpd ID I-6 | US11576906, Compound I-6 ...)
Affinity DataIC50: 550nMAssay Description:Compound 1 was not initially reported as having the greatest biochemical potency compared to reports for certain other small molecule inhibitors of m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2023
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132H](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 550716BDBM550716(US11376246, Cpd ID I-6 | US11576906, Compound I-6 ...)
Affinity DataIC50: 550nMAssay Description:Please see paper.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 550716BDBM550716(US11376246, Cpd ID I-6 | US11576906, Compound I-6 ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Compound 1 was not initially reported as having the greatest biochemical potency compared to reports for certain other small molecule inhibitors of m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/31/2023
Entry Details
US Patent

TargetIsocitrate dehydrogenase [NADP] cytoplasmic [R132C](Human)
Forma Therapeutics

US Patent
LigandChemical structure of BindingDB Monomer ID 550716BDBM550716(US11376246, Cpd ID I-6 | US11576906, Compound I-6 ...)
Affinity DataIC50: 1.00E+4nMAssay Description:Please see paper.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2022
Entry Details
US Patent