BDBM550811 7-(2,4-Difluorophenyl)-8-(2-methyl-6-(trifluoromethyl)pyridin-4-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine 18::US11312705, Example 18

SMILES Cc1cc(cc(n1)C(F)(F)F)-c1c(nc(N)n2cnnc12)-c1ccc(F)cc1F

InChI Key InChIKey=KDHCZXJVJYRVEB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 550811   

TargetAdenosine receptor A2a(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550811(7-(2,4-Difluorophenyl)-8-(2-methyl-6-(trifluoromet...)
Affinity DataIC50: 0.75nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550811(7-(2,4-Difluorophenyl)-8-(2-methyl-6-(trifluoromet...)
Affinity DataIC50: 0.75nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A2a(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550811(7-(2,4-Difluorophenyl)-8-(2-methyl-6-(trifluoromet...)
Affinity DataIC50: 3.96nMAssay Description:CHO-K1/A2aR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 800 μg/ml bleomycin. The cells were digested with the c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A3(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550811(7-(2,4-Difluorophenyl)-8-(2-methyl-6-(trifluoromet...)
Affinity DataIC50: 104nMAssay Description:CHO-K1/A3R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 10 μg/ml puromycin. The cells were digested with the cel...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A1(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550811(7-(2,4-Difluorophenyl)-8-(2-methyl-6-(trifluoromet...)
Affinity DataIC50: 409nMAssay Description:CHO-K1/A1R cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 1 mg/ml G418. The cells were digested with the cell separatio...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent

TargetAdenosine receptor A2b(Human)
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM550811(7-(2,4-Difluorophenyl)-8-(2-methyl-6-(trifluoromet...)
Affinity DataIC50: 793nMAssay Description:CHO-K1/A2bR cells were cultured in DMEM/F12 medium containing 10% fetal bovine serum and 1 mg/ml G418. The cells were digested with the cell separati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2022
Entry Details
US Patent