BDBM55094 N-[3-chloro-4-(2,5-diketo-3-phenyl-pyrrolidino)phenyl]picolinamide::N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)phenyl]-2-pyridinecarboxamide::N-[3-chloro-4-(2,5-dioxo-3-phenylpyrrolidin-1-yl)phenyl]pyridine-2-carboxamide::N-[4-[2,5-bis(oxidanylidene)-3-phenyl-pyrrolidin-1-yl]-3-chloranyl-phenyl]pyridine-2-carboxamide::VU0400071-3::cid_45110765

SMILES Oc1cc(c(O)n1-c1ccc(NC(=O)c2ccccn2)cc1Cl)-c1ccccc1

InChI Key InChIKey=OCVJQOGGFDUYFY-UHFFFAOYSA-N

Data  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 55094   

TargetMetabotropic glutamate receptor 4 [Q124R](Rat)
Vanderbilt Screening Center For Gpcrs, Ion Channels and Transporters

Curated by PubChem BioAssay
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataEC50:  490nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetMetabotropic glutamate receptor 4(Rat)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataEC50:  491nMAssay Description:Positive allosteric modulator activity at rat mGlu4 receptor by thallium flux assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataEC50:  674nMAssay Description:Positive allosteric modulator activity at human mGlu4 receptor expressed in CHO cells expressing Gqi5 by calcium mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataEC50:  823nMAssay Description:Assay Provider: Colleen Niswender Assay Provider Affiliation: Vanderbilt University The primary pathophysiological change giving rise to the symptoms...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/5/2011
Entry Details
PCBioAssay
TargetCytochrome P450 2C9(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using 4-hydroxydiclofenac as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of CYP1A2 in human liver microsomes using acetaminophen as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of CYP2C19 in human liver microsomes using S-mephenytoin as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using 1-hydroxymidazolam as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM55094(N-[3-chloro-4-(2,5-dioxo-3-phenyl-1-pyrrolidinyl)p...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of CYP2D6 in human liver microsomes using dextrophan tartarate as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed