BDBM551490 (R)-9-fluoro-2-(1-(6-isopropoxypyridin-3-yl)piperidin-3-yl)- 7-methoxy-[1,2,4]triazolo[1,5-c]quinazolin-5-amine::US11312719, Example 35

SMILES COc1cc(F)cc2c3nc(nn3c(N)nc12)[C@@H]1CCCN(C1)c1ccc(OC(C)C)nc1

InChI Key InChIKey=XSXYEWFEZSYZCO-CQSZACIVSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 551490   

TargetAdenosine receptor A2b(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551490((R)-9-fluoro-2-(1-(6-isopropoxypyridin-3-yl)piperi...)
Affinity DataIC50:  12.2nMAssay Description:The reported affinity of the compounds of the invention for the human A2b adenosine receptor was determined experimentally using a radioligand filtra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetAdenosine receptor A2a(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM551490((R)-9-fluoro-2-(1-(6-isopropoxypyridin-3-yl)piperi...)
Affinity DataIC50:  0.600nMAssay Description:148 μL (5 μg/mL) membranes (Perkin Elmer, Cat. No. RBHA2aM400UA) and 2 μL compounds of the invention to be tested (test compound) were...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent