BDBM552872 (R)-3-(3-(5-Fluoro-2-(1H-pyrrolo[2,3-b]pyridin-3-yl)thlazol-4-yl)phenyl)-3-hydroxy-1-methylpyrrolidin-2-one.::WO2022104348, Example 99

SMILES CN1CC[C@](O)(C1=O)c1cccc(c1)-c1nc(sc1F)-c1c[nH]c2ncccc12

InChI Key InChIKey=RBVDOPVDBZHDJJ-OAQYLSRUSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 552872   

TargetMitogen-activated protein kinase kinase kinase 14(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM552872((R)-3-(3-(5-Fluoro-2-(1H-pyrrolo[2,3-b]pyridin-3-y...)
Affinity DataIC50: <100nMAssay Description:NIK/MAP3K14 auto-phosphorylation activity was measured using the AlphaScreenŽ (ascreen) format (Perkin Elmer). All compound6 tested were dissolved in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed