BDBM556057 1-((3S,5R)-1-Acryloyl-5-(methoxymethyl)pyrrolidin-3-yl-3-((1-cyclobutyl-6-fluoro-1H-benzo[d]imidazol-5-yl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide::US11345681, Example 230

SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@H](COC)N(C1)C(=O)C=C)C#Cc1cc2ncn(C3CCC3)c2cc1F

InChI Key InChIKey=BCOJIDFRCFXQSL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 556057   

LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of FGFR3 K650M mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild type FGFR1 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 1.10nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of FGFR2 N549H mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 5.80nMAssay Description:Inhibition of FGFR2 V564F mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 5.90nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556057(US11345681, Example 230 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent