BDBM556064 1-((3S,5R)-1-Acryloyl-5-(methoxymethyl)pyrrolidin-3-yl-3-((6-fluoro-1-isopropyl-1H-benzo[d]imidazol-5-yl)ethynyl)-5-(methylamino)-1H-pyrazole-4-carboxamide::US11345681, Example 237

SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@H](COC)N(C1)C(=O)C=C)C#Cc1cc2ncn(C(C)C)c2cc1F

InChI Key InChIKey=VRWGJEGSNQCDOR-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 556064   

LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 2.80nMAssay Description:Inhibition of wild type FGFR2 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type FGFR1 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of FGFR3 K650M mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type FGFR3 (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of AT...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of FGFR2 V564F mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 13nMAssay Description:Inhibition of FGFR2 N549H mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 54nMAssay Description:Inhibition of FGFR3 V555M mutant (unknown origin) using 5-FAM-KKKKEEIYFFF-CONH2 peptide as fluorogenic substrate incubated for 80 mins in presence of...More data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
LigandPNGBDBM556064(US11345681, Example 237 | 1-((3S,5R)-1-Acryloyl-5-...)
Affinity DataIC50: 100nMAssay Description:Small molecule inhibition of FGFR2 kinase activity was evaluated using a fluorescence-based microfluidic mobility shift assay. FGFR2 catalyzes the pr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/5/2022
Entry Details
US Patent