BDBM556328 (S)—N-(5-(3-(dimethylamino)pyrrolidin-1-yl)pyridin-2-yl)-5-fluoro-4-(5-fluoro-1,1-dimethyl-2,3-dihydro-1H-benzo[d]pyrrolo[1,2-a]imidazol-7-yl)pyrimidin-2-amine (Compound 49)::US11351170, Example 7

SMILES CN(C)[C@H]1CCN(C1)c1ccc(Nc2ncc(F)c(n2)-c2cc(F)c3nc4CCC(C)(C)n4c3c2)nc1

InChI Key InChIKey=PJROIFLISSJQQQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 556328   

TargetCyclin-dependent kinase 4(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556328(US11351170, Example 7 | (S)—N-(5-(3-(dimethyl...)
Affinity DataIC50: 0.180nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 6(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556328(US11351170, Example 7 | (S)—N-(5-(3-(dimethyl...)
Affinity DataIC50: 3.96nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were respectively dissolved in ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 5(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556328(US11351170, Example 7 | (S)—N-(5-(3-(dimethyl...)
Affinity DataIC50: 50.6nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent

TargetCyclin-dependent kinase 2(Human)
Beijing Xuanyi Pharmasciences

US Patent
LigandPNGBDBM556328(US11351170, Example 7 | (S)—N-(5-(3-(dimethyl...)
Affinity DataIC50: 65.5nMAssay Description:Test compounds (compound of the present invention, reference compound Abemaciclib, and comparative example compounds) were dissolved in DMSO at 10 mM...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
US Patent