BDBM557405 6-[4-amino-1-(3- methoxypropyl) pyrazolo [3,4-d]pyrimidin- 3-yl]-N- methyl-1H-indole-2- carboxamide::US11352361, Example 54::US11680068, Example 54

SMILES CNC(=O)c1cc2ccc(cc2[nH]1)-c1nn(CCCOC)c2ncnc(N)c12

InChI Key InChIKey=ZJFARYIPQGNKQJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 557405   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557405(US11352361, Example 54 | 6-[4-amino-1-(3- methoxyp...)
Affinity DataIC50: 374nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557405(US11352361, Example 54 | 6-[4-amino-1-(3- methoxyp...)
Affinity DataIC50: 374nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557405(US11352361, Example 54 | 6-[4-amino-1-(3- methoxyp...)
Affinity DataIC50: 2.93E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM557405(US11352361, Example 54 | 6-[4-amino-1-(3- methoxyp...)
Affinity DataIC50: 2.93E+4nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2023
Entry Details
US Patent