BDBM558708 US11365204, Example 63::[1-[(5R)-4-[methyl- (tetrahydropyran-4- yl)amino]-5-oxido-6,7- dihydrothieno[3,2- d]pyrimidin-5-ium-2- yl]azetidin-3-yl] pyridine-3-carboxylate

SMILES CN(C1CCOCC1)c1nc(nc2CC[S@@+](O)c12)N1CC(C1)OC(=O)c1cccnc1

InChI Key InChIKey=LKZYRYDEERVIGP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 558708   

TargetTumor necrosis factor(Human)
Union Therapeutics

US Patent
LigandPNGBDBM558708(US11365204, Example 63 | [1-[(5R)-4-[methyl- (tetr...)
Affinity DataIC50: 100nMAssay Description:Human peripheral blood mononuclear cells (PBMC) were isolated from fresh buffy coats by density centrifugation using lymphoprep tubes (Medinor). Froz...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Human)
Union Therapeutics

US Patent
LigandPNGBDBM558708(US11365204, Example 63 | [1-[(5R)-4-[methyl- (tetr...)
Affinity DataIC50: 300nMAssay Description:The human PDE4D catalytic domain (UniProt no. Q08499 [S380-L740]) was incubated with a mixture of non-labelled cAMP (cyclic adenosine monophosphate) ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent