BDBM558723 1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-((1-methyl-1H-::US11365205, Example 1

SMILES Cn1cnc2ccc(CN3CCN(CC(O)CN4CCc5ccccc5C4)C3=O)cc12

InChI Key InChIKey=WGLDMWPZXFXJCC-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558723   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 558723BDBM558723(1-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypr...)
Affinity DataIC50: 430nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent