BDBM558779 3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-4,4-dimethyl-1-(4-::US11365205, Example 45

SMILES CC1(C)CN(Cc2ccc(cc2)S(C)(=O)=O)C(=O)N1CC(O)CN1CCc2ccccc2C1

InChI Key InChIKey=XKQDHYRXTDNLBJ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558779   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 558779BDBM558779(3-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypr...)
Affinity DataIC50: 110nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent