BDBM558814 3-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-1-(4-methylbenzyl)-4-::US11365205, Example 81

SMILES Cc1ccc(CN2CC(N(CC(O)CN3CCc4ccccc4C3)C2=O)c2ccccc2)cc1

InChI Key InChIKey=RQKAFTSMUVCZHU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 558814   

TargetMethylosome protein 50/Protein arginine N-methyltransferase 5(Human)
Aurigene Discovery Technologies

US Patent
LigandChemical structure of BindingDB Monomer ID 558814BDBM558814(3-(3-(3,4-Dihydroisoquinolin-2(1H)-yl)-2-hydroxypr...)
Affinity DataIC50: 610nMAssay Description:Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that catalyze mono- and symmetric demethylation on arginine resi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2022
Entry Details
US Patent