BDBM560634 (2R,4R)-1-(2,6- dichlorobenzyl)-4- ((3-fluoro-6-((5-methyl- 1H-pyrazol-3-yl)amino) pyridin-2-yl)methyl)-2- methylpiperidine- 4-carboxylic acid::US11384066, Example 17

SMILES Cc1cc(Nc2ccc(F)c(C[C@@]3(C(=O)O)CCN(Cc4c(Cl)cccc4Cl)[C@H](C)C3)n2)n[nH]1

InChI Key InChIKey=ACTXWWQHJRICMT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 560634   

TargetAurora kinase A(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560634BDBM560634(US11384066, Example 17 | (2R,4R)-1-(2,6- dichlorob...)
Affinity DataIC50: 3.20nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent

TargetAurora kinase B(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560634BDBM560634(US11384066, Example 17 | (2R,4R)-1-(2,6- dichlorob...)
Affinity DataIC50: 9.52E+3nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent