BDBM560658 (2R,4R)-1-(3-chloro-2-fluoro benzyl)-4-((4-chloro-5-fluoro- 6-((5-methyl-1H-pyrazol-3- yl)amino)pyridin-2-yl)methyl)- 2-methylpiperidine-4- carboxylic acid::US11384066, Example 73

SMILES Cc1cc(Nc2nc(C[C@@]3(C(=O)O)CCN(Cc4cccc(Cl)c4F)[C@H](C)C3)cc(Cl)c2F)n[nH]1

InChI Key InChIKey=FMSSVKVRLRCICW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 560658   

TargetAurora kinase A(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560658BDBM560658(US11384066, Example 73 | (2R,4R)-1-(3-chloro-2-flu...)
Affinity DataIC50: 0.760nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent

TargetAurora kinase B(Human)
Jacobio Pharmaceuticals

US Patent
LigandChemical structure of BindingDB Monomer ID 560658BDBM560658(US11384066, Example 73 | (2R,4R)-1-(3-chloro-2-flu...)
Affinity DataIC50: 592nMAssay Description:Experimental Methods:(1) Prepare a 1× kinase buffer [50 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid (HEPES), PH 7.5, 0.01% Brij-35, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2022
Entry Details
US Patent