BDBM561455 US11390625, Compound 41::US11390625, Example 41

SMILES CCc1cc(Nc2ncc(Br)c(Nc3ccc4nccnc4c3P(C)(C)=O)n2)c(OC)cc1N1CCC(CC1)N1CCN(C)CC1

InChI Key InChIKey=ZABBRQASQVBFDE-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 561455   

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM561455(US11390625, Compound 41 | US11390625, Example 41)
Affinity DataIC50: 0.212nMAssay Description:Inhibition of EGFR Del19/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor [1-18,20-1210,T790M,C797S](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561455(US11390625, Compound 41 | US11390625, Example 41)
Affinity DataIC50: 0.212nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Chia Tai Tianqing Pharmaceutical Group

US Patent
LigandPNGBDBM561455(US11390625, Compound 41 | US11390625, Example 41)
Affinity DataIC50: 0.260nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM561455(US11390625, Compound 41 | US11390625, Example 41)
Affinity DataIC50: 0.260nMAssay Description:Inhibition of EGFR L858R/T790M/C797S triple mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM561455(US11390625, Compound 41 | US11390625, Example 41)
Affinity DataIC50: 5.10nMAssay Description:Inhibition of wild type EGFR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/23/2023
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
H. R. Patel Institute of Pharmaceutical Education and Research

Curated by ChEMBL
LigandPNGBDBM561455(US11390625, Compound 41 | US11390625, Example 41)
Affinity DataIC50: 5.12nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/17/2022
Entry Details
US Patent