BDBM562355 (rac)-1-(3-(4-Chloro-3,5-dimethylphenoxy)propyl)-13-fluoro-8,11,12-trimethyl-5,6,9,11-tetrahydro-4H,8H-pyrazolo[3′,4′:4,5][1]thia[2,8]diazacycloundecino[6,7,8-hi]indole-2-carboxylic acid 7,7-dioxide::US11401278, Example 28

SMILES CN1Cc2nn(C)c(C)c2-c2c(F)ccc3c(CCCOc4cc(C)c(Cl)c(C)c4)c(C(O)=O)n(CCCS1(=O)=O)c23

InChI Key InChIKey=JNQZXBDFQCIYEW-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562355   

LigandPNGBDBM562355(US11401278, Example 28 | (rac)-1-(3-(4-Chloro-3,5-...)
Affinity DataIC50: 4nMAssay Description:MCL-1/Noxa BH3 Peptide (MCL-1 Assay): From there, 50 nl were transferred in a dark test plate (Greiner Bio-One, Frickenhausen, Germany). The assay wa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandPNGBDBM562355(US11401278, Example 28 | (rac)-1-(3-(4-Chloro-3,5-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-2/Bad BH3 Peptide (BCL-2 Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-2 solution (usually for a 1 ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent

LigandPNGBDBM562355(US11401278, Example 28 | (rac)-1-(3-(4-Chloro-3,5-...)
Affinity DataIC50: 2.00E+4nMAssay Description:BCL-XL/Bad BH3 Peptide (BCL-XL Assay): The assay was initiated by addition of 2 μl of a 2.5-fold concentrated His-BCL-XL solution (usually for a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2022
Entry Details
US Patent