BDBM562757 (2S,5R,6S)-2-Benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one and (2R,5S,6R)-2-benzyl-5,6-bis(4-chlorophenyl)-4-methylmorpholin-3-one::US11407721, Example 4

SMILES CN1[C@H]([C@H](O[C@H](Cc2ccccc2)C1=O)c1ccc(Cl)cc1)c1ccc(Cl)cc1

InChI Key InChIKey=NFFXQTHZDQEVMP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 562757   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562757BDBM562757(US11407721, Example 4 | (2S,5R,6S)-2-Benzyl-5,6-bi...)
Affinity DataIC50: 1.76E+3nMAssay Description:The standard assay conditions for the in vitro HTRF assay consisted of a 50 ul total reaction volume in black 384-well Costar polypropylene plates in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562757BDBM562757(US11407721, Example 4 | (2S,5R,6S)-2-Benzyl-5,6-bi...)
Affinity DataIC50: 1.00E+4nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562757BDBM562757(US11407721, Example 4 | (2S,5R,6S)-2-Benzyl-5,6-bi...)
Affinity DataIC50: 2.14E+4nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent