BDBM562773 (2S,5R,6S)-6-(3-Chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(3-hydroxypropyl)morpholin-3-one and (2R,5S,6R)-6-(3-chlorophenyl)-5-(4-chlorophenyl)-4-(cyclopropylmethyl)-2-(3-hydroxypropyl)morpholin-3-one::US11407721, Example 19

SMILES OCCC[C@@H]1O[C@H]([C@H](N(CC2CC2)C1=O)c1ccc(Cl)cc1)c1cccc(Cl)c1

InChI Key InChIKey=PMULZUULMROOQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 562773   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562773BDBM562773(US11407721, Example 19 | (2S,5R,6S)-6-(3-Chlorophe...)
Affinity DataIC50: 6.91E+3nMAssay Description:This assay was run using the same conditions as the HTRF1 assay except that 20 uL of GST-hMDM2 was incubated with 1.0 ul of diluted compound.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562773BDBM562773(US11407721, Example 19 | (2S,5R,6S)-6-(3-Chlorophe...)
Affinity DataIC50: 7.23E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/28/2022
Entry Details
US Patent