BDBM562796 (R)-2-((2S,3R)-2-(4-Chlorophenyl)-3-(1H-indol-2-yl)-5-oxomorpholino)pentanoic acid and (S)-2-((2R,3S)-2-(4-Chlorophenyl)-3-(1H-indol-2-yl)-5-oxomorpholino)pentanoic acid::US11407721, Example 43

SMILES CCC[C@H](C(=O)O)N1C(=O)CO[C@@H](c2ccc(Cl)cc2)[C@H]1c1cc2ccccc2[nH]1

InChI Key InChIKey=HQRAQGJHPUFZPL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 562796   

TargetE3 ubiquitin-protein ligase Mdm2 [1-188](Human)
Amgen

US Patent
LigandChemical structure of BindingDB Monomer ID 562796BDBM562796(US11407721, Example 43 | (R)-2-((2S,3R)-2-(4-Chlor...)
Affinity DataIC50: 1.29E+3nMAssay Description:As the potencies of the HDM2 inhibitors increased, an improved HTRF assay (HTRF2 assay) was developed. All assay conditions remained the same as desc...More data for this Ligand-Target Pair
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Date in BDB:
10/28/2022
Entry Details
US Patent